Recent Publications
Mahamud MR, Geng X, Chen L, Ahmed Z, Ho Y, Srinivasan RS (2022). GATA2 regulates blood/lymph separation in a platelet-dependent and lymphovenous valve-independent manner. Microcirculation. Oct 5:e12787. doi: 10.1111/micc.12787.
Geng X, Chen L, Srinivasan RS, Kylat RJ, Witte MH, Erickson RJ (2022). Lack of embryonic homozygous or adult heterozygous lymphatic phenotypes for a Sos1 mutation and lack of lymphatic embryonic phenotypes for a homozygous Cx47 mutation in mice. Lymphology. 2022;55(3):129-134.
Ho Y, Geng X, Ibarrola J, Fernandez-Celis, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Matsuzaki F, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, Lopez-Andres N, Bischoff J, Srinivasan RS. PROX1 inhibits PDGF-B expression to prevent myxomatous degeneration of heart valves. (Under revision for Circulation Research).
Geng X, Yanagida K, Akwii RG, Choi D, Chen L, Ho Y, Cha B, Mahamud MR, de Ruiz KB, Ichise H, Chen H, Wythe J, Hong YK, Mikelis CM, Hla T, Srinivasan RS (2020). S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. JCI Insight. (cover image), 5(14):e137652. doi: 10.1172/jci.insight.137652. PMID: 32544090 PMCID: PMC7453895
Woods JP, Srinivasan RS, Olson LE. Sweet Dre-ams about intersectional genetics. Cell Stem Cell 28:989-990, 2021 June, PMID: 34087159
Chen D, Geng X, Lapinski PE, Davis MJ, Srinivasan RS, King PD. RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice. Development, 2020 January, PMID: 33144395
Cha B, Ho YC, Geng X, Mahamud MR, Chen L, Kim Y, Choi D, Kim TH, Randolph GJ, Cao X, Chen H, Srinivasan RS. YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling. Development, 2020 January, PMID: 33060128
Selected Publications
Srinivasan RS, Dillard ME, Lagutin OV, Lin FJ, Tsai S, Tsai MJ, Samokhvalov IM, Oliver G. Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature. Genes Dev. 2007 Oct 1;21(19):2422-32. PMID: 17908929 PMCID: PMC1993873
Srinivasan RS, Geng X, Yang Y, Wang Y, Mukatira S, Studer M, Porto MP, Lagutin O, Oliver G. The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev. 2010 Apr 1;24(7):696-707. PMID: 22012621 PMCID: PMC3205588
Srinivasan RS, Oliver G. Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes Dev. 2011 Oct 15;25(20):2187-97. PMCID: PMC3205588
Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G. The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes Dev. 2014 Oct 1;28(19):2175-87. PMID: 25274728 PMCID: PMC4180978
Geng X, Cha B, Mahamud MR, Lim KC, Silasi-Mansat R, Uddin MK, Miura N, Xia L, Simon AM, Engel JD, Chen H, Lupu F, Srinivasan RS (2016). Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol. (cover image), 409(1):218-33. PMID: 26542011 PMCID: PMC4688075
Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS (2016). Mechanotransduction activates canonical Wnt/beta-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes Dev. (cover image), 30(12):1454-69. PMID: 27313318 PMCID: PMC4926867
Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS (2018). Complementary Wnt sources regulate lymphatic vascular development via PROX1-dependent Wnt/ß-catenin signaling. Cell Reports (cover image), 25(3):571-584. PMID: 30332639 PMCID: PMC6264919
Crosswhite PL, Podsiadlowska JJ, Curtis CD, Gao S, Xia L, Srinivasan RS, Griffin CT. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. J Clin Invest. 2016 Jun 1;126(6):2254-66. PMID: 27140400 PMCID: PMC4887170
Liu X, Pasula S, Song H, Tessneer KL, Dong Y, Hahn S, Yago T, Brophy ML, Chang B, Cai X, Wu H, McManus J, Ichise H, Georgescu C, Wren JD, Griffin C, Xia L, Srinivasan RS, Chen H. Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function. Sci Signal. 2014 Oct 14;7(347):ra97. PMID: 25314967 PMCID: PMC4226761